학술논문
First-Line Antituberculosis Drug Concentrations in Infants With HIV and a History of Recent Admission With Severe Pneumonia.
Document Type
Article
Author
Chabala, Chishala; Jacobs, Tom G; Moraleda, Cinta; Ndaferankhande, John M; Mumbiro, Vivian; Passanduca, Alfeu; Namuziya, Natasha; Nalwanga, Damalie; Musiime, Victor; Ballesteros, Alvaro; Domínguez-Rodríguez, Sara; Chitsamatanga, Moses; Cassia, Uneisse; Nduna, Bwendo; Bramugy, Justina; Sacarlal, Jahit; Madrid, Lola; Nathoo, Kusum J; Colbers, Angela; Burger, David M
Source
Subject
*ANTIBIOTICS
*DRUG therapy for tuberculosis
*HIV-positive persons
*PNEUMONIA
*HIV infections
*ETHAMBUTOL
*GLOMERULAR filtration rate
*RESEARCH
*CO-trimoxazole
*PREDNISOLONE
*BODY weight
*BLOOD plasma
*MULTIVARIATE analysis
*PYRAZINAMIDE
*MULTIPLE regression analysis
*PATIENTS
*ANTIRETROVIRAL agents
*BLOOD collection
*HOSPITAL admission & discharge
*SEVERITY of illness index
*ISONIAZID
*ANTITUBERCULAR agents
*RESEARCH funding
*VALGANCICLOVIR
*DESCRIPTIVE statistics
*RIFAMPIN
*CHILDREN
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Language
ISSN
2048-7193
Abstract
Optimal antituberculosis therapy is essential for favorable clinical outcomes. Peak plasma concentrations of first-line antituberculosis drugs in infants with living HIV receiving WHO-recommended dosing were low compared with reference values for adults, supporting studies on increased doses of first-line TB drugs in infants. [ABSTRACT FROM AUTHOR]