학술논문
Blood pressure and metabolic phenotypes in relation to the ADRB1 Arg389Gly and ADRA2B I/D polymorphisms in a White population.
Document Type
Article
Author
Source
Subject
*BLOOD pressure
*CHROMOSOME polymorphism
*CHOLESTEROL
*LIPOPROTEINS
*SERUM
*OBESITY
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Language
ISSN
0950-9240
Abstract
Previous studies of cases and controls or selected patients demonstrated association of the ADRB1 Arg389Gfy and ADRA2B I/D polymorphisms with blood pressure, measures of obesity, and/or serum lipidia. In multivariate-adjusted analyses of 1881 subjects randomly recruited from a White population, ADRBl ArgArg homozygotes, compared with Gly alíele carriers, had higher diastolic blood pressure (79.4 vs 78.4mmHg; P=0.012), and higher serum high-density lipoprotein (HDL) cholesterol (1.33 vs l^mmoU"1; P = 0.020), whereas none of the other cardiovascular or metabolic phenotypes reached significance in relation to the two polymorphisms. Our family-based design excluded population stratification as a possible explanation for the significant association of the ADRBl Arg389Gly polymorphism with blood pressure and HDL cholesterol. [ABSTRACT FROM AUTHOR]