학술논문
Circulating Vitamin D Level and Its Impact on Mortality and Recurrence in Stage III Colorectal Cancer Patients: A Systematic Review and Meta-Analysis.
Document Type
Article
Author
Ottaiano, Alessandro; Facchini, Sergio; Santorsola, Mariachiara; Nasti, Guglielmo; Facchini, Gaetano; Montella, Liliana; Maurea, Nicola; Cascella, Marco; Iervolino, Domenico; Facchini, Bianca Arianna; Montopoli, Monica; Consolo, Pierluigi; Quagliariello, Vincenzo; Rinaldi, Luca; Berretta, Massimiliano
Source
Subject
*DISEASE progression
*ADJUVANT chemotherapy
*ONLINE information services
*META-analysis
*CONFIDENCE intervals
*PREOPERATIVE period
*SYSTEMATIC reviews
*CANCER relapse
*VITAMIN D
*COLORECTAL cancer
*RISK assessment
*TREATMENT effectiveness
*CANCER patients
*TUMOR classification
*DESCRIPTIVE statistics
*TUMOR markers
*PROGRESSION-free survival
*STATISTICAL models
*MEDLINE
*DATA analysis software
*OVERALL survival
*PROPORTIONAL hazards models
*DISEASE risk factors
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Language
ISSN
2072-6694
Abstract
Simple Summary: We conducted a systematic review and meta-analysis to investigate the relationship between pre-operative vitamin D (VD) levels and time-to-outcome in stage III colorectal cancer (CRC) patients. Four articles were included in the analysis, with pooled data from 2628 patients for overall survival and 2024 patients for disease-free survival. The results showed that patients with lower levels of VD had a 38% and 13% increased risk of death and recurrence, respectively, according to random-effects models. These findings suggest that a low VD concentration negatively impacts the time-to-outcome in stage III CRC. Background: Vitamin D (VD) has been implicated in several diseases, including colorectal cancer (CRC). This study aimed to determine whether there is an association between VD levels and time-to-outcome in stage III CRC patients through a systematic review and meta-analysis. Methods: The study adhered to the PRISMA 2020 statement. Articles were searched in PubMed/MEDLINE and Scopus/ELSEVIER. Four articles were selected, with the primary objective of providing a pooled estimate of the risk of death specifically in stage III CRC patients based on pre-operative VD levels. Study heterogeneity and publication bias were analyzed using Tau2 statistics and funnel plots. Results: The selected studies showed significant heterogeneity regarding time-to-outcome, technical assessments, and serum VD concentration measures. The pooled analysis of 2628 and 2024 patients revealed a 38% and 13% increase in the risk of death (HR: 1.38, 95% CI: 0.71–2.71) and recurrence (HR: 1.13; 95% CI: 0.84–1.53), respectively, for random-effects models among patients with lower levels of VD. Conclusions: Our findings suggest that a low concentration of VD has a significant negative impact on time-to-outcome in stage III CRC. [ABSTRACT FROM AUTHOR]