학술논문
A safe Synthesis of 1,5-Disubstituted 3-Amino-1H-1,2,4-triazoles from 1,3,4-Oxadiazolium Hexafluorophosphates.
Document Type
Article
Source
Subject
*TRIAZOLES synthesis
*AMINO acids
*CHEMICAL synthesis
*CALCIUM cyanamide
*TRIETHYLAMINE
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Language
ISSN
0039-7881
Abstract
Hexafluorophosphoric acid promotes 1,3,4-oxadiazolium hexafluorophosphate formation from N'-acyl-N-aroyl-N-arylhydrazides or N'-acyl-N-acyl-N-arylhydrazides under mild conditions. These 1,3,4-oxadiazolium hexafluorophosphates can be treated with cyanamide in propan-2-ol in the presence of triethylamine to generate 1,5-disubstituted 3-amino-1H-1,2,4-triazoles in good yields. This safe and scalable protocol displays a broad scope with respect to N-substitutions and N'-acyl protecting groups. [ABSTRACT FROM AUTHOR]