학술논문
SOCS-3 regulates onset and maintenance of TH 2-mediated allergic responses.
Document Type
Article
Author
Seki, Yoh-ichi; Inoue, Hiromasa; Nagata, Naoko; Hayashi, Katsuhiko; Fukuyama, Satoru; Matsumoto, Koichiro; Komine, Okiru; Hamano, Shinjiro; Himeno, Kunisuke; Inagaki-Ohara, Kyoko; Cacalano, Nicholas; O'Garra, Anne; Oshida, Tadahiro; Saito, Hirohisa; Johnston, James A.; Yoshimura, Akihiko; Kubo, Masato
Source
Subject
*CYTOKINES
*T cells
*ALLERGIES
*ANTIALLERGIC agents
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Language
ISSN
1078-8956
Abstract
Members of the suppressor of cytokine signaling (SOCS) family are involved in the pathogenesis of many inflammatory diseases. SOCS-3 is predominantly expressed in T-helper type 2 (TH2) cells, but its role in TH2-related allergic diseases remains to be investigated. In this study we provide a strong correlation between SOCS-3 expression and the pathology of asthma and atopic dermatitis, as well as serum IgE levels in allergic human patients. SOCS-3 transgenic mice showed increased TH2 responses and multiple pathological features characteristic of asthma in an airway hypersensitivity model system. In contrast, dominant-negative mutant SOCS-3 transgenic mice, as well as mice with a heterozygous deletion of Socs3, had decreased TH2 development. These data indicate that SOCS-3 has an important role in regulating the onset and maintenance of TH2-mediated allergic immune disease, and suggest that SOCS-3 may be a new therapeutic target for the development of antiallergic drugs. [ABSTRACT FROM AUTHOR]