학술논문
Exploration of the Rapid Effects of Personal Fine Particulate Matter Exposure on Arterial Hemodynamics and Vascular Function during the Same Day.
Document Type
Article
Author
Source
Subject
*COLLECTION & preservation of biological specimens
*AIR pollution
*BLOOD pressure
*ENDOTHELIUM
*HEART beat
*HEMODYNAMICS
*PROBABILITY theory
*RESEARCH
*RESEARCH funding
*STATISTICAL sampling
*SYMPATHETIC nervous system
*TIME
*ENVIRONMENTAL exposure
*BRACHIAL artery
*PARTICULATE matter
*EQUIPMENT & supplies
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Language
ISSN
0091-6765
Abstract
Background: Levels of fine particulate matter [≤2.5 μm in aerodynamic diameter (PM2.5)] are associated with alterations in arterial hemodynamics and vascular function. However, the characteristics of the same-day exposure.response relationships remain unclear. Objectives: We aimed to explore the effects of personal PM2.5 exposures within the preceding 24 hr on blood pressure (BP), heart rate (HR), brachial artery diameter (BAD), endothelial function [flow-mediated dilatation (FMD)], and nitroglycerin-mediated dilatation (NMD). Methods: Fifty-one nonsmoking subjects had up to 5 consecutive days of 24-hr personal PM2.5 monitoring and daily cardiovascular (CV) measurements during summer and/or winter periods. The associations between integrated hour-long total personal PM2.5 exposure (TPE) levels (continuous nephelometry among compliant subjects with low secondhand tobacco smoke exposures; n.=.30) with the CV outcomes were assessed over a 24-hr period by linear mixed models. Results: We observed the strongest associations (and smallest estimation errors) between HR and TPE recorded 1.10 hr before CV measurements. The associations were not pronounced for the other time lags (11--24 hr). The associations between TPE and FMD or BAD did not show as clear a temporal pattern. However, we found some suggestion of a negative association with FMD and a positive association with BAD related to TPE just before measurement (0--2 hr). Conclusions: Brief elevations in ambient TPE levels encountered during routine daily activity were associated with small increases in HR and trends toward conduit arterial vasodilatation and endothelial dysfunction within a few hours of exposure. These responses could reflect acute PM2.5-induced autonomic imbalance and may factor in the associated rapid increase in CV risk among susceptible individuals. [ABSTRACT FROM AUTHOR]