부산대학교 도서관

Objectives: The ECGnoct study intends to evaluate the modifications of the ST segment and of the T wave in nurses working night shifts. Methods: ECGnoct is enrolling female nurses. Up to now, 38 nurses completed the baseline examination protocol. The medical history, the number of years of night shift work and the average of night shifts/month are documented and anthropometric parameters, blood pressure, fasting glucose, tryglicerides and HDL-cholesterol are measured. For this analysis, the ECG recorded in the morning was evaluated. QT was corrected by the Framingham formula (QTcFr). The Tpeak to Tend (in V5) was adjusted to the QT duration. Regression (Backward method) was used to find the best correlation between the independent variables (age, waist circumference, a previous diagnosis of cardiovascular disease, glycemia, serum triglycerides and HDL-cholesterol) and the TpTe/QT and the QTc. Results: The average age was 42.10 years (+ 8.03). The nurses had worked, on average, 10.55 years (+ 10.39) years of night shift; the mean number of shifts/months was 3.86 (+2.84). High level of triglycerides was recorded in 10 cases, while 8 participants had low HDL-cholesterol and 8 had high glycemia. The best regression model for the TpTe/QT included the number of night shifts/month and the waist circumference as predictors (R squared=0.217, p=0.017). In what concerns the QtcFr, the best model maintained only the age as independent factor (R squared=0.234, p=0.002). Conclusion:These preliminary data support the assumption that both occupational and non-occupational risk factors interact to influence the transmural dispersion of the left ventricle repolarization. [ABSTRACT FROM AUTHOR]