학술논문
Transcriptome-guided characterization of genomic rearrangements in a breast cancer cell line.
Document Type
Article
Author
Source
Subject
*CANCER cells
*GENOMICS
*BREAST cancer
*CELL lines
*CIRCULAR DNA
*GENETICS
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Language
ISSN
0027-8424
Abstract
We have identified new genomic alterations in the breast cancer cell line HCC1954, using high-throughput transcriptome sequencing. With 120 Mb of cDNA sequences, we were able to identify genomic rearrangement events leading to fusions or truncations of genes including MRE11 and NSD1, genes already implicated in oncogenesis, and 7 rearrangements involving other additional genes. This approach demonstrates that high-throughput transcriptome sequencing is an effective strategy for the characterization of genomic rearrangements in cancers. [ABSTRACT FROM AUTHOR]