학술논문
Disease-Specific Survival of Type I and Type II Epithelial Ovarian Cancers—Stage Challenges Categorical Assignments of Indolence & Aggressiveness.
Document Type
Article
Author
Pavlik, Edward J.; Smith, Christopher; Dennis, Taylor S.; Harvey, Elizabeth; Huang, Bin; Chen, Quan; West Piecoro, Dava; Burgess, Brian T.; McDowell, Anthony; Gorski, Justin; Baldwin, Lauren A.; Miller, Rachel W.; DeSimone, Christopher P.; Dietrich III, Charles; Gallion, Holly H.; Ueland, Frederick R.; van Nagell, John R.
Source
Subject
*OVARIAN epithelial cancer
*LAZINESS
*OVARIAN cancer
*SURVIVAL analysis (Biometry)
*
*
*
Language
ISSN
2075-4418
Abstract
Epithelial ovarian cancers (EOC) consist of several sub-types based on histology, clinical, molecular and epidemiological features that are termed "histo-types", which can be categorized into less aggressive Type I and more aggressive Type II malignancies. This investigation evaluated the disease-specific survival (DSS) of women with Type I and II EOC using histo-type, grade, and stage. A total of 47,789 EOC cases were identified in the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) data. Survival analysis and log rank test were performed to identify a 2-tiered classification (grade 1 vs. grade 2 & 3) for serous EOC. DSS of early stage serous EOC for grade 2 was significantly different from grade 3 indicating that a 2-tier classification for serous EOC applied only to late stage. DSS of Type I EOC was much better than Type II. However, DSS was 33–52% lower with late stage Type I than with early stage Type I indicating that Type I ovarian cancers should not be considered indolent. Early stage Type II EOC had much better DSS than late stage Type II stressing that stage has a large role in survival of both Type I and II EOC. [ABSTRACT FROM AUTHOR]