학술논문
No association between rs6897932 in the gene encoding interleukin-7 receptor α and low-grade inflammation or self-reported health - results from the Danish Blood Donor Study.
Document Type
Article
Author
Source
Subject
*ALLELES
*SINGLE nucleotide polymorphisms
*INTERLEUKIN-7 receptors
*MONONUCLEOSIS
*INFLAMMATION
*QUALITY of life
*GENETICS of autoimmune diseases
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Language
ISSN
0903-4641
Abstract
The T-allele in the single nucleotide polymorphism rs6897932 in the gene encoding the IL-7 receptor α ( IL7 RA) is associated with reduced risk of autoimmune diseases including multiple sclerosis and also affects the course of HIV infection. Low-grade inflammation ( LGI) and self-reported, health-related quality of life ( HRQL) are often associated with chronic diseases and widely used in assessing and monitoring health status. The aim of the present study was to evaluate whether the T-allele in rs6897932 is associated with reduced risk of LGI (hs CRP 3-10 mg/L), history of infectious mononucleosis ( IM), and HRQL in healthy individuals. A total of 17, 293 healthy Danish individuals from the Danish Blood Donor Study were included in the analyses. We tested rs6897932 as a predictor of LGI, self-reported IM, and HRQL in univariable and multivariable models stratified by sex. No associations between rs6897932 and LGI, self-reported IM or HRQL were found in men or women. This suggests that rs6897932 is not associated with general inflammation, and the reported associations between the T-allele in rs6897932 with several autoimmune diseases may be mediated through effects on a restricted part of the immune system. [ABSTRACT FROM AUTHOR]