학술논문
Selective Terminal Functionalization of Linear Alkanes**.
Document Type
Article
Author
Source
Subject
*DEHYDROGENATION
*RHODOCOCCUS
*ALKENES
*BIOCATALYSIS
*BACTERIA
*ELECTROPHILES
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Language
ISSN
0044-8249
Abstract
A two‐step sequential strategy involving a biocatalytic dehydrogenation/remote hydrofunctionalization, as a unified and versatile approach to selectively convert linear alkanes into a large array of valuable functionalized aliphatic derivatives is reported. The dehydrogenation is carried out by a mutant strain of a bacteria Rhodococcus and the produced alkenes are subsequently engaged in a remote functionalization through a metal‐catalyzed hydrometalation/migration sequence that subsequently react with a large variety of electrophiles. The judicious implementation of this combined biocatalytic and organometallic approach enabled us to develop a high‐yielding protocol to site‐selectively functionalize unreactive primary C−H bonds. [ABSTRACT FROM AUTHOR]