학술논문
Associations of marijuana with markers of chronic lung disease in people living with HIV.
Document Type
Article
Author
Source
Subject
*CHRONIC disease risk factors
*BIOMARKERS
*CANNABIS (Genus)
*CONFIDENCE intervals
*PULMONARY emphysema
*HIV infections
*HIV-positive persons
*LUNG diseases
*REGRESSION analysis
*RESPIRATORY measurements
*LOGISTIC regression analysis
*CROSS-sectional method
*DESCRIPTIVE statistics
*ODDS ratio
*DISEASE risk factors
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Language
ISSN
1464-2662
Abstract
Objectives: The relationship between marijuana use and markers of chronic lung disease in people living with HIV (PLWH) is poorly understood. Methods: We performed a cross‐sectional analysis of the Examinations of HIV‐Associated Lung Emphysema (EXHALE) study, including 162 HIV‐positive patients and 138 participants without HIV. We modelled marijuana exposure as: (i) current daily or weekly marijuana smoking vs. monthly or less often; or (ii) cumulative marijuana smoking (joint‐years). Linear and logistic regression estimated associations between marijuana exposure and markers of lung disease, adjusted for tobacco smoking and other factors. Results: In PLWH, current daily or weekly marijuana use was associated with a larger forced vital capacity (FVC), larger total lung capacity and increased odds of radiographic emphysema compared with marijuana non‐smokers in adjusted models; these associations were not statistically significant in participants without HIV. Marijuana joint‐years were associated with higher forced expiratory volume in 1 s and FVC in PLWH but not with emphysema. Conclusions: In PLWH, marijuana smoking was associated with higher lung volumes and potentially with radiographic emphysema. No consistently negative associations were observed between marijuana and measures of chronic lung health. [ABSTRACT FROM AUTHOR]