학술논문
Associations between plasma sulfur amino acids and specific fat depots in two independent cohorts: CODAM and The Maastricht Study.
Document Type
Article
Author
Tore, Elena C.; Elshorbagy, Amany K.; Bakers, Frans C. H.; Brouwers, Martijn C. G. J.; Dagnelie, Pieter C.; Eussen, Simone J. P. M.; Jansen, Jacobus F. A.; Kooi, M. Eline; Kusters, Yvo H. A. M.; Meex, Steven J. R.; Olsen, Thomas; Refsum, Helga; Retterstøl, Kjetil; Schalkwijk, Casper G.; Stehouwer, Coen D. A.; Vinknes, Kathrine J.; van Greevenbroek, Marleen M. J.
Source
Subject
*OBESITY risk factors
*OBESITY complications
*SULFUR amino acids
*BODY composition
*CYSTEINE
*HOMOCYSTEINE
*GLUTATHIONE
*SKINFOLD thickness
*PHOTON absorptiometry
*CONFIDENCE intervals
*CROSS-sectional method
*LIQUID chromatography
*ABDOMINAL adipose tissue
*REGRESSION analysis
*METHIONINE
*NON-alcoholic fatty liver disease
*METABOLIC disorders
*RISK assessment
*DESCRIPTIVE statistics
*MASS spectrometry
*RESEARCH funding
*WAIST circumference
*BODY mass index
*LOGISTIC regression analysis
*ODDS ratio
*ADIPOSE tissues
*LONGITUDINAL method
*PREDIABETIC state
*DISEASE risk factors
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Language
ISSN
1436-6207
Abstract
Purpose: Sulfur amino acids (SAAs) have been associated with obesity and obesity-related metabolic diseases. We investigated whether plasma SAAs (methionine, total cysteine (tCys), total homocysteine, cystathionine and total glutathione) are related to specific fat depots. Methods: We examined cross-sectional subsets from the CODAM cohort (n = 470, 61.3% men, median [IQR]: 67 [61, 71] years) and The Maastricht Study (DMS; n = 371, 53.4% men, 63 [55, 68] years), enriched with (pre)diabetic individuals. SAAs were measured in fasting EDTA plasma with LC–MS/MS. Outcomes comprised BMI, skinfolds, waist circumference (WC), dual-energy X-ray absorptiometry (DXA, DMS), body composition, abdominal subcutaneous and visceral adipose tissues (CODAM: ultrasound, DMS: MRI) and liver fat (estimated, in CODAM, or MRI-derived, in DMS, liver fat percentage and fatty liver disease). Associations were examined with linear or logistic regressions adjusted for relevant confounders with z-standardized primary exposures and outcomes. Results: Methionine was associated with all measures of liver fat, e.g., fatty liver disease [CODAM: OR = 1.49 (95% CI 1.19, 1.88); DMS: OR = 1.51 (1.09, 2.14)], but not with other fat depots. tCys was associated with overall obesity, e.g., BMI [CODAM: β = 0.19 (0.09, 0.28); DMS: β = 0.24 (0.14, 0.34)]; peripheral adiposity, e.g., biceps and triceps skinfolds [CODAM: β = 0.15 (0.08, 0.23); DMS: β = 0.20 (0.12, 0.29)]; and central adiposity, e.g., WC [CODAM: β = 0.16 (0.08, 0.25); DMS: β = 0.17 (0.08, 0.27)]. Associations of tCys with VAT and liver fat were inconsistent. Other SAAs were not associated with body fat. Conclusion: Plasma concentrations of methionine and tCys showed distinct associations with different fat depots, with similar strengths in the two cohorts. [ABSTRACT FROM AUTHOR]