부산대학교 도서관

Group A Streptococcus (GAS) is a Gram‐positive bacterial pathogen that causes significant morbidity and mortality worldwide. Recent clinical evidence suggests that the inflammatory marker interleukin‐1β (IL‐1β) plays an important role in GAS disease progression, and presents a potential target for therapeutic intervention. Interaction with GAS activates the host inflammasome pathway to stimulate production and secretion of IL‐1β, but GAS can also stimulate IL‐1β production in an inflammasome‐independent manner. This review highlights progress that has been made in understanding the importance of host cell inflammasomes and IL‐1 signalling in GAS disease, and explores challenges and unsolved problems in this host‐pathogen interaction. Take Away: Inflammasome signalling during GAS infection is an emerging field of research.GAS modulates the NLRP3 inflammasome pathway through multiple mechanisms.SpeB contributes to IL‐1β production independently of the inflammasome pathway.IL‐1β signalling can be host‐protective, but also drive severe GAS disease. [ABSTRACT FROM AUTHOR]