학술논문
Amber alert: getting to the heart of succinate efflux in reperfusion injury.
Document Type
Article
Author
Source
Subject
*REPERFUSION injury
*EFFLUX (Microbiology)
*LACTATES
*KREBS cycle
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Language
ISSN
0008-6363
Abstract
The accumulation of succinate under hypoxic/ischaemic conditions is conserved across diverse tissues and species, 2 and succinate accumulatedduringischaemiaplaysacentralroleinmediatingdamageupontissue reperfusion, i.e., ischaemia-reperfusion (IR) injury. 3 There are two proposed mechanisms of ischaemic succinate accumulation: in one, reversal of mitochondrial succinate dehydrogenase (complex II) reduces fumarate to succinate, while in the other, succinate originates from canonicalKrebs'cycleactivitywithcomplexIIinhibitedduetoreductionof the co-enzyme Q pool. [Extracted from the article]