학술논문
Identification, Replication, and Fine-Mapping of Loci Associated with Adult Height in Individuals of African Ancestry.
Document Type
Article
Author
N'Diaye, Amidou; Chen, Gary K.; Palmer, Cameron D.; Ge, Bing; Tayo, Bamidele; Mathias, Rasika A.; Ding, Jingzhong; Nalls, Michael A.; Adeyemo, Adebowale; Adoue, Véronique; Ambrosone, Christine B.; Atwood, Larry; Bandera, Elisa V.; Becker, Lewis C.; Berndt, Sonja I.; Bernstein, Leslie; Blot, William J.; Boerwinkle, Eric; Britton, Angela; Casey, Graham
Source
Subject
*HERITABILITY
*GENEALOGY
*GENETIC research
*AFRICANS
*STATURE
*EUROPEANS
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Language
ISSN
1553-7390
Abstract
Adult height is a classic polygenic trait of high heritability (h² ~0.8). More than 180 single nucleotide polymorphisms (SNPs), identified mostly in populations of European descent, are associated with height. These variants convey modest effects and explain ~10% of the variance in height. Discovery efforts in other populations, while limited, have revealed loci for height not previously implicated in individuals of European ancestry. Here, we performed a meta-analysis of genome-wide association (GWA) results for adult height in 20,427 individuals of African ancestry with replication in up to 16,436 African Americans. We found two novel height loci (Xp22-rs12393627, P = 3.4x10-12 and 2p14-rs4315565, P = 1.2x10-8). As a group, height associations discovered in European-ancestry samples replicate in individuals of African ancestry (P = 1.7x10-4 for overall replication). Fine-mapping of the European height loci in African-ancestry individuals showed an enrichment of SNPs that are associated with expression of nearby genes when compared to the index European height SNPs (P<0.01). Our results highlight the utility of genetic studies in non-European populations to understand the etiology of complex human diseases and traits. [ABSTRACT FROM AUTHOR]