학술논문
Analysis of Nigerians with Apparently Sporadic Parkinson Disease for Mutations in LRRK2, PRKN and ATXN3.
Document Type
Article
Author
Source
Subject
*PARKINSON'S disease patients
*NIGERIANS
*HUMAN genetic variation
*GENES
*NONSENSE mutation
*COHORT analysis
*POPULATION
*DISEASES
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Language
ISSN
1932-6203
Abstract
Several genetic variations have been associated with Parkinson disease in different populations over the past few years. Although a considerable number of worldwide populations have been screened for these variants, results from Sub-Saharan populations are very scarce in the literature. In the present report we have screened a cohort of Parkinson disease patients (n = 57) and healthy controls (n = 51) from Nigeria for mutations in the genes PRKN, LRRK2 and ATXN3. No pathogenic mutations were found in any of the genes. Hence, common pathogenic mutations in these genes, observed in several different populations, are not a frequent cause of Parkinson disease in Nigeria. [ABSTRACT FROM AUTHOR]