학술논문
Synthesis and antiproliferative activity of novel organotin complexes bearing abiraterone drug moiety.
Document Type
Article
Author
Source
Subject
*ABIRATERONE acetate
*MOIETIES (Chemistry)
*CELL cycle
*CANCER cells
*ANTINEOPLASTIC agents
*BENZENESULFONAMIDES
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*
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Language
ISSN
0959-9436
Abstract
[Display omitted] Novel organotin(iv) complexes based on anticancer drug abiraterone acetate and abiraterone incorporating semipolar N→Sn bond at the pyridine moiety were synthesized and characterized. In vitro antiproliferative activity of the complexes against human cancer and normal cell lines was evaluated, the complexes with triphenyltin moiety being the most active (IC 50 is in the range of 120–430 nm). Compounds actively induced apoptosis and blocked proliferation in the G2/M phase of the cell cycle. [ABSTRACT FROM AUTHOR]