학술논문
Functional magnetic resonance imaging of human motor unit fasciculation in amyotrophic lateral sclerosis.
Document Type
Journal Article
Author
Source
Subject
*DIFFUSION magnetic resonance imaging
*MOTOR unit
*FUNCTIONAL magnetic resonance imaging
*AMYOTROPHIC lateral sclerosis
*LEG
*CLINICAL trials
*COMPARATIVE studies
*MAGNETIC resonance imaging
*RESEARCH methodology
*MEDICAL cooperation
*NEUROLOGIC examination
*NEUROMUSCULAR manifestations of general diseases
*RESEARCH
*RESEARCH funding
*EVALUATION research
*CASE-control method
*SKELETAL muscle
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Language
ISSN
0364-5134
Abstract
A novel diffusion-weighted magnetic resonance imaging protocol sensitive to contraction of individual skeletal motor units was developed. We applied this technique to the lower limb muscles of 4 patients with confirmed amyotrophic lateral sclerosis (ALS) and 6 healthy controls. A 3-minute scan revealed florid fasciculation in ALS patients, involving both superficial and deep muscles, and at a frequency higher than in healthy controls. This novel imaging technique reveals hitherto unobtainable information on human motor unit structure and function, which may allow earlier diagnosis and recruitment to clinical trials. ANN NEUROL 2019;85:455-459. [ABSTRACT FROM AUTHOR]