학술논문
Interleukin 31 transcription in a canine model of acute atopic dermatitis does not correlate with T‐cell infiltration.
Document Type
Article
Author
Source
Subject
*GENETIC transcription
*ATOPIC dermatitis
*T cells
*MAST cell tumors
*ECZEMA
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Language
ISSN
0105-4538
Abstract
This article discusses a study that examines the role of interleukin 31 (IL-31) in the development of atopic dermatitis (AD) in dogs. The researchers used a naturally occurring canine model of AD to investigate IL-31 transcription in the skin during acute and chronic inflammation. They found that IL-31 transcription was low or undetectable during acute inflammation and increased during chronic inflammation. The study suggests that IL-31 transcription in atopic skin may be attributable to infiltrating cells, such as eosinophils and macrophages, rather than CD3+ T cells. Further research is needed to identify the specific cells involved in IL-31 signaling in atopic skin. [Extracted from the article]