학술논문
Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes.
Document Type
Article
Author
Vogelezang, Suzanne; Bradfield, Jonathan P.; the Early Growth Genetics Consortium; Johansson, Stefan; Stergiakouli, Evie; Thiering, Elisabeth; Pennell, Craig E.; Ahluwalia, Tarunveer S.; Karhunen, Ville; Scholz, Markus; Liu, Xueping; Iñiguez, Carmen; Raitakari, Olli T.; Bacelis, Jonas; Schnurr, Theresia M.; Lakka, Timo A.; Ntalla, Ioanna; Lind, Mads V.; Lauritzen, Lotte; Herrala, Sauli
Source
Subject
*GENETIC correlations
*GENOME-wide association studies
*GENETICS
*PHENOTYPES
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Language
ISSN
1755-8794
Abstract
Background: Head circumference is associated with intelligence and tracks from childhood into adulthood. Methods: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age. Results: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes. Conclusions: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics. [ABSTRACT FROM AUTHOR]