부산대학교 도서관

We discuss the study by McNamara I et al., i who report that low levels of antigen-specific antibodies in serum can limit the boosting of antibody and B-cell responses following immunization with live attenuated malaria sporozoites. Importantly, the research findings of McNamara I et al i . may inform several approaches that could be used to overcome antibody feedback in future vaccine development, such as altered vaccine scheduling, and modified vaccine constructs or antigen dosage (Figure 1). Potential strategies to overcome epitope masking and enhance current vaccine approaches include delayed vaccine dosing, modified vaccine construct design, and increased vaccine antigen doses. [Extracted from the article]