학술논문
New developments in our understanding of ankylosing spondylitis pathogenesis.
Document Type
Article
Author
Source
Subject
*PATHOLOGY
*ANKYLOSING spondylitis
*GUT microbiome
*MONOCLONAL antibodies
*IMMUNE response
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Language
ISSN
0019-2805
Abstract
Summary: Ankylosing spondylitis (AS) is a common immune‐mediated inflammatory arthritis with a strong genetic predisposition. We review recent data from genetic and animal studies highlighting the importance of Type 17 immune responses. Furthermore, the efficacy (or lack thereof) of different anti‐cytokine monoclonal antibodies has highlighted the diversity of Type 17 immune cells and cytokines critical to AS and related spondyloarthritis pathogenesis. Recent studies have strongly implicated the gut microbiome in AS. Finally, we propose that the local metabolic environment of the joint may have a key role in driving AS, and present a novel model of AS pathogenesis. [ABSTRACT FROM AUTHOR]