학술논문
Epigenetic changes in the metabolically healthy obese: A case‐control versus a prospective study.
Document Type
Article
Author
Source
Subject
*METABOLIC disorders
*EPIGENETICS
*LONGITUDINAL method
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Language
ISSN
0014-2972
Abstract
DISCUSSION This study presented an epigenome-wide DNA methylation analysis for the epigenetic changes in the MUO phenotype, using both the case-control and prospective designs, with a follow-up of 11 years. Overall, in the case-control approach, we observed that the average global DNA methylation was decreased in the MUO group ( I p i < 0.001) (Figure 1C), whereas in the prospective design, individuals with MUO at 11-years follow-up showed increased average global DNA methylation in comparison with subjects at baseline (MHO) ( I p i < 0.001). Obesity has become a worldwide health problem, in which latest statistics reported an increased trend over the last years. DNA isolation, bisulfite reaction and epigenome-wide DNA methylation analysis DNA was extracted from peripheral blood using the QIAmp DNA Blood Mini Kit (Qiagen, Hilden, Germany). [Extracted from the article]