학술논문
Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect?
Document Type
Journal Article
Source
Subject
*ATHEROSCLEROSIS risk factors
*VASCULITIS
*IMMUNE response
*CARDIOVASCULAR disease prevention
*INFLAMMATION
*ANTI-inflammatory agents
*THERAPEUTIC use of antioxidants
*BIOTHERAPY
*VITAMIN therapy
*ANTILIPEMIC agents
*CARDIOVASCULAR diseases
*CYTOKINES
*ESTERASES
*RELATIVE medical risk
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Language
ISSN
0007-1188
Abstract
Data from basic science experiments is overwhelmingly supportive of the causal role of immune-inflammatory response(s) at the core of atherosclerosis, and therefore, the theoretical potential to manipulate the inflammatory response to prevent cardiovascular events. However, extrapolation to humans requires care and we still lack definitive evidence to show that interfering in immune-inflammatory processes may safely lessen clinical atherosclerosis. In this review, we discuss key therapeutic targets in the treatment of vascular inflammation, placing basic research in a wider clinical perspective, as well as identifying outstanding questions.Linked Articles: This article is part of a themed section on Targeting Inflammation to Reduce Cardiovascular Disease Risk. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.22/issuetoc and http://onlinelibrary.wiley.com/doi/10.1111/bcp.v82.4/issuetoc. [ABSTRACT FROM AUTHOR]