학술논문
Ultrasound-assisted synthesis of 2-amino-1,3,4-oxadiazoles through NBS-mediated oxidative cyclization of semicarbazones.
Document Type
Article
Author
Source
Subject
*OXADIAZOLES
*CHEMICAL synthesis
*ULTRASONIC imaging
*SEMICARBAZONES
*RING formation (Chemistry)
*BROMOSUCCINIMIDE
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Language
ISSN
0039-7911
Abstract
A ultrasound-assisted oxidative cyclization of semicarbazones using N-bromosuccinimide in the presence of sodium acetate was established providing efficient and rapid access to a variety of 2-amino-1,3,4-oxadiazoles. Moreover, the new synthetic protocol provides a simple procedure utilizing a safer oxidizing system that affords the target products in high regioselectivity, satisfactory yields, and elevated purities. [ABSTRACT FROM AUTHOR]