학술논문
Atypical astroglial pTDP‐43 pathology in astroglial predominant tauopathy.
Document Type
Article
Author
Gelpi, Ellen; Aldecoa, Iban; Lopez‐Villegas, Dolores; Abellan‐Vidal, Maria Teresa; Mercadel‐Fañanas, Pilar; Fortea, Juan; Ribosa, Roser; Morenas, Estrella; Gomez‐Anson, Beatriz; Molina‐Porcel, Laura; Ximelis, Teresa; Borrego, Sergi; Antonell, Anna; Rovelet‐Lecrux, Anne; Klotz, Sigrid; Andres‐Benito, Pol; Sanchez‐Valle, Raquel; Ferrer, Isidre
Source
Subject
*PATHOLOGY
*TAU proteins
*GRANULE cells
*AMYOTROPHIC lateral sclerosis
*FRONTAL lobe
*MOTOR neuron diseases
*MONOCLONAL antibodies
*NEUROFIBRILLARY tangles
*TAUOPATHIES
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Language
ISSN
0305-1846
Abstract
Josephs et al. reported that preinclusions might be better identified with antibodies against full-length TDP-43.3 This astrocytic pTDP-43 pathology clearly followed the pathology pattern observed with the AT8 antibody at the cellular and anatomical level. Keywords: astroglial tauopathy; FTLD-Tau; glia limitans/perivascular glia; pTDP-43; TDP-43 EN astroglial tauopathy FTLD-Tau glia limitans/perivascular glia pTDP-43 TDP-43 1109 1113 5 11/24/21 20211201 NES 211201 We observed atypical astrocytic pTDP-43 pathology in astroglial predominant tauopathy. Glial and neuronal tau pathology in tauopathies: characterization of disease-specific phenotypes and tau pathology progression. Whether the dual pTDP-43 and pTau pathology represents a specific disease signature and whether potential protein-interactions lead to this complex pathology deserves further studies. [Extracted from the article]