학술논문
Recurrent involvement of ring-type zinc finger genes in complex molecular rearrangements in childhood acute myelogeneous leukemia with translocation t(10;11)(p12;q23).
Document Type
Article
Author
Source
Subject
*REARRANGEMENTS (Chemistry)
*MYELOID leukemia genetics
*LYMPHOCYTIC leukemia
*ACUTE myeloid leukemia
*NUCLEOTIDE sequence
*CHROMOSOMES
*HUMAN genetic variation
*POLYMERASE chain reaction
*GENETICS
*
*
*
*
*
*
*
*
Language
ISSN
0887-6924
Abstract
The article presents a study which examines the rearrangement of myeloid/lymphoid leukemia (MLL) and MLLT10 fusion gene in pediatric patients with acute myelogeneous leukemia (AML). It says that paired-end sequencing was used to detect the pattern of molecular rearrangement and other related chromosomes. Findings reveal several structural variants in leukemic subjects and confirm the MLL/MLLT10 breakpoint in some patients using polymerase chain reaction (PCR) and capillary sequencing.