학술논문
Inborn errors of immunity illuminate mechanisms of human immunology and pave the road to precision medicine.
Document Type
Article
Source
Subject
*AUTOIMMUNE diseases
*INDIVIDUALIZED medicine
*RHEUMATOID arthritis
*IMMUNOLOGY
*IMMUNITY
*JOB'S syndrome
*MEDICAL specialties & specialists
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Language
ISSN
0105-2896
Abstract
This document discusses the field of immune dysregulation and its role in advancing precision medicine for immune dysregulation disorders. It highlights the discovery of monogenic disorders that impact Treg cell function, known as Tregopathies, and reviews the first Tregopathy disorder called FOXP3 deficiency or IPEX. The document also explores the use of targeted therapies, such as JAK inhibitors and IL-1 blockade, in the treatment of immune dysregulation disorders. It further discusses the challenges and advancements in gene therapy approaches for immune dysregulation disorders. The document emphasizes the importance of collaboration, data sharing, and continued research in the field of immune dysregulation to improve patient outcomes. [Extracted from the article]