학술논문
A Concise Synthetic Method for Constructing 3-Substituted Piperazine-2-Acetic Acid Esters from 1,2-Diamines.
Document Type
Article
Author
Source
Subject
*ENANTIOMERIC purity
*ESTERS
*ACETIC acid
*DIAMINES
*AMINO acids
*PIPERAZINE
*RACEMIZATION
*
*
*
*
*
*
Language
ISSN
1420-3049
Abstract
We report a short synthetic route for synthesizing 2,3-substituted piperazine acetic acid esters. Optically pure amino acids were efficiently converted into 1,2-diamines that could be utilized to deliver the title 2,3-substituted piperazines in five steps with a high enantiomeric purity. The novel route facilitated, for the first time, the synthesis of 3-phenyl substituted-2-piperazine acetic acid esters that were difficult to achieve using other methods; however, in this case, the products underwent racemization. [ABSTRACT FROM AUTHOR]