학술논문
Normal meninges harbor oncogenic somatic mutations in meningioma-driver genes.
Document Type
Article
Author
Boetto, Julien; Plu, Isabelle; Ducos, Yohan; Blouin, Antoine; Teranishi, Yu; Letournel, Franck; Martin-Négrier, Marie-Laure; Faisant, Maxime; Godfraind, Catherine; Maurage, Claude-Alain; Deramecourt, Vincent; Duchesne, Mathilde; Meyronnet, David; Delteil, Clémence; Rigau, Valérie; Vandenbos-Burel, Fanny; Seilhean, Danielle; Boluda, Susana; Chiforeanu, Dan Christian; Marguet, Florent
Source
Subject
*SOMATIC mutation
*MENINGES
*DURA mater
*GENETIC variation
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Language
ISSN
0001-6322
Abstract
The occurrence of I TRAF7 i mutations in the normal meninges also questions its intrinsic pathogenic value, since meningiomas frequently harbor a second co-mutation ( I KLF4 i SP I K409Q i sp or one of the main oncogenes of the PI3K pathway, I AKT1 i and I PIK3CA i ) [[1], [5]]. Meningioma oncogenesis is dominated by the occurrence of well-known driver gene mutations that form co-exclusive mutational groups, but 20% of meningiomas do not harbor any somatic mutation [[4]-[6]]. Variants are reported ordered by gene mutation frequency, and colored depending on the consequence of the mutation. d Summary of the four mutations present in the normal meninges in main driver genes for meningioma (NF2 and TRAF7). [Extracted from the article]