학술논문
Richter transformation – retrospective treatment outcomes analysis in Polish Adult Leukemia Study Group.
Document Type
Article
Author
Sośnia, Oktawia; Pruszczyk, Katarzyna; Danecki, Michał; Wąsik-Szczepanek, Ewa; Tryc-Szponder, Jagoda; Iskierka-Jażdżewska, Elżbieta; Majeranowski, Alan; Krzemień, Helena; Bołkun, Łukasz; Paszkiewicz-Kozik, Ewa; Drozd-Sokołowska, Joanna; Kwiatkowski, Jacek; Wiśniewska-Organek, Dominika; Prochorec-Sobieszek, Monika; Szumera-Ciećkiewicz, Anna; Budziszewska, Bożena; Jamroziak, Krzysztof; Hus, Iwona; Lech-Marańda, Ewa; Puła, Bartosz
Source
Subject
*RICHTER syndrome
*HEMATOPOIETIC stem cell transplantation
*DIFFUSE large B-cell lymphomas
*CHRONIC lymphocytic leukemia
*LEUKEMIA
*TREATMENT effectiveness
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Language
ISSN
1042-8194
Abstract
Richter transformation (RT) is defined as developing an aggressive lymphoma in 2–10% of patients suffering from chronic lymphocytic leukemia (CLL). So far, no complex analysis of RT demographics and treatment outcomes has been performed in Poland. Thus, the retrospective analysis of 124 patients with RT from Polish hematology centers was designed. Ninety-nine patients with diffuse large B-cell lymphoma (DLBCL-RT) were identified. The median overall survival (OS) for DLBCL-RT was 17.3 months, while for Hodgkin lymphoma (HL-RT)-21.3 months. In multivariate analysis, the independent factors of worse OS for DLBCL-RT were: prior CLL therapy, ECOG stage ≥2, and elevated serum LDH activity. Patients who proceeded to hematopoietic stem cell transplantation (HSCT) achieved better results. The median OS in allogeneic HSCT recipients was not reached, while in autologous HSCT median OS was 51.3 months. In conclusion, our study represents the largest dataset of patients diagnosed with RT in Poland and confirms its dismal prognosis. [ABSTRACT FROM AUTHOR]