학술논문
Radiogenomics Analysis of Intratumor Heterogeneity in a Patient With High-Grade Serous Ovarian Cancer.
Document Type
Case Study
Author
Weigelt, Britta; Vargas, Hebert Alberto; Selenica, Pier; Geyer, Felipe C.; Mazaheri, Yousef; Blecua, Pedro; Conlon, Niamh; Hoang, Lien N.; Jungbluth, Achim A.; Snyder, Alexandra; Ng, Charlotte K.Y.; Papanastasiou, Anastasios D.; Sosa, Ramon E.; Soslow, Robert A.; Chi, Dennis S.; Gardner, Ginger J.; Shen, Ronglai; Reis-Filho, Jorge S.; Sala, Evis
Source
Subject
*OVARIAN cancer
*CIRCULATING tumor DNA
*HETEROGENEITY
*RENAL cell carcinoma
*POSITRON emission tomography
*ECHO-planar imaging
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Language
ISSN
2473-4284
Abstract
The article describes the radiogenomics evaluation of intratumor heterogeneity in a 69-year-old woman with high-grade serous ovarian cancer (HGSOC). Case highlights include whole-exome sequencing of the micro-dissected tumor and matched normal deoxyribonucleic acid samples, evaluation of three right ovarian mass HGSOC imaging-based habitats and the omental implant, and method used to identify phenotypically distinct areas of an HGSOC.