학술논문
Synthesis of some novel piperidine fused 5-thioxo-1H-1,2,4-triazoles as potential antimicrobial and antitubercular agents.
Document Type
Article
Author
Source
Subject
*ANTITUBERCULAR agents
*ANTI-infective agents
*PIPERIDINE
*MYCOBACTERIUM tuberculosis
*STRUCTURE-activity relationships
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Language
ISSN
0974-3626
Abstract
A novel series of analogues based on 5-(1-(4-chloro-3-methoxyphenyl)piperidin-4-yl)-4-phenyl-2H-1,2,4-triazole-3(4H)-thione core have been synthesized and their potential as antibacterial, antifungal and antitubercular agents was examined. The structure-activity relationship (SAR) studies of these derivatives 5 (a–k) clearly indicate the vital role of lipophilicity as a major factor in enhancing the biological activity of these compounds. Among the compounds screened, 5a, 5c, 5d, 5j and 5k displayed significant activity against Mycobacterium tuberculosis H37Rv strain. [ABSTRACT FROM AUTHOR]