부산대학교 도서관

Background: In the inflammatory bowel disease literature, emergency surgery for Crohn's disease (CD) is associated with worse postoperative outcomes as compared to elective surgery. Previous studies have compared heterogeneous groups only. We hypothesized that this association would be lost after matched analysis. We aimed to compare matched CD patients undergoing elective vs emergency surgery. Methods: The National Surgical Quality Improvement database (01/2005–12/2019) was utilized to identify adult CD surgical patients. Univariate and conditional logistic regression models were used to analyze unmatched and matched cohorts. Propensity-score matching was performed to match emergency to non-emergency patients 1:1. Our primary outcome was a composite of any complication. Our secondary endpoints were hospital readmission, unplanned reoperation and 30-day morbidity and mortality. Results: In the unmatched analyses (n = 12,181/95.28% elective and n = 603/4.72% emergency) of Crohn's patients undergoing colectomy, 20% of elective and 42% of emergency patients experienced a complication (p < 0.001). Over 20 outcomes measured including length of stay (LOS), readmission, infections and respiratory, cardiovascular and renal complications, were worse in the emergency cohort. In the matched analyses (n = 400 emergency/400 elective patients) only the categories of any complication (OR 1.44, 1.06–1.96 95% CI, p = 0.02), any surgical site infection (SSI, OR 1.53, 1.07–2.19 95% CI, p = 0.02), superficial SSI (OR 2.25, 1.14–4.44 95% CI, p = 0.02), organ space SSI (1.58 OR 1.04–2.4 95% CI, p = 0.03), unplanned intubation (OR 5.0, 1.45–17.27 95% CI, p = 0.01), ventilation > 48 h (OR 9.0, 1.4–38.79 95% CI, p = 0.003) and septic shock (OR 4.5, 1.86–10.9 95% CI, p < 0.001) were higher in the emergency cohort. Conclusions: Matching CD patients resulted in a loss of the observed increase in cardiovascular and renal complications, reoperation and LOS following emergency surgery; however, SSIs and respiratory complications remained increased despite matching. [ABSTRACT FROM AUTHOR]