학술논문
Common variants near TERC are associated with mean telomere length.
Document Type
Article
Author
Codd, Veryan; Mangino, Massimo; van der Harst, Pim; Braund, Peter S.; Kaiser, Michael; Beveridge, Alan J.; Rafelt, Suzanne; Moore, Jasbir; Nelson, Chris; Soranzo, Nicole; Guangju Zhai; Valdes, Ana M.; Blackburn, Hannah; Leach, Irene Mateo; de Boer, Rudolf A.; Goodall, Alison H.; Ouwehand, Willem; van Veldhuisen, Dirk J.; van Gilst, Wiek H.; Navis, Gerjan
Source
Subject
*TELOMERES
*CHROMOSOMES
*GENOMES
*LEUCOCYTES
*RNA
*
*
*
*
Language
ISSN
1061-4036
Abstract
We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 × 10−14) at a locus that includes TERC, which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an ∼75-base-pair reduction in mean telomere length, equivalent to ∼3.6 years of age-related telomere-length attrition. [ABSTRACT FROM AUTHOR]