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ABBREVIATIONS ABC America's Blood Centers ACBTSA Advisory Committee on Blood and Tissue Safety and Availability HHS Department of Health and Human Services OASH Office of the Assistant Secretary for Health The abrupt decrease in blood use coinciding with the 2008-2009 recession dramatically altered US blood collection agency financial performance (Fig.). [Color figure can be viewed at wileyonlinelibrary.com] gl Questioning the sustainability of the US blood system, in 2015 the Department of Health and Human Services (HHS) commissioned the RAND Corporation to conduct a broad study of the US blood system and to identify options to ensure its long-term sustainability. Three themes emerged: 1) enhance critical transfusion medicine-blood and safety innovation focused on outcomes; 2) establish a data collection system supported by data analytics across the supply chain from suppliers to vein-to-vein; and 3) assure transfusion medicine preparedness. [Extracted from the article]