학술논문
Low Risk of Nevirapine Resistance Mutations in the Prevention of Mother-to-Child Transmission of HIV-1: Agence Nationale de Recherches sur le SIDA Ditrame Plus, Abidjan, Côte d'Ivoire.
Document Type
Report
Author
Source
Subject
*HIV
*HIV infection transmission
*AZIDOTHYMIDINE
*MOTHER-infant relationship
*MULTIVARIATE analysis
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Language
ISSN
0022-1899
Abstract
The frequency of resistance mutations was estimated in the cohort of Agence Nationale de Recherches sur le SIDA Ditrame Plus, a study that evaluated the combination of short-course zidovudine (ZDV) plus lamivudine (3TC) and single- dose nevirapine (SD-NVP) followed by 3 days of postpartum ZDV plus 3TC for the prevention of mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1). The frequency with which resistance mutations were detected in mothers at week 4 postpartum was 1.14% (95% confidence interval [CI], 0.03%-6.17%) for NVP and 8.33% (95% CI, 3.66%-15.76%) for 3TC. In multivariate analysis, 3TC resistance was associated with a longer duration of ZDV plus 3TC prepartum prophylaxis (P = .009). This regimen, which is feasible in resource-limited settings, prevents most peripartum HIV- 1 transmission and minimizes the development of NVP resistance. [ABSTRACT FROM AUTHOR]