학술논문
Chromosomal Alterations Detected by Fluorescence In Situ Hybridization in Urothelial Carcinoma and Rarer Histologic Variants of Bladder Cancer.
Document Type
Article
Author
Source
Subject
*CHROMOSOME abnormalities
*BLADDER cancer
*DIAGNOSTIC use of fluorescence in situ hybridization
*HISTOPATHOLOGY
*URINARY organ cancer
*CLINICAL pathology
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Language
ISSN
0002-9173
Abstract
Fluorescence in situ hybridization (FISH) with the UroVysion probe set (Abbott Molecular, Des Plaines, IL) was used to assess 31 bladder cancers for chromosomal abnormalities, including 4 adenocarcinomas, 5 urachal adenocarcinomas, 6 small cell carcinomas, 7 squamous cell carcinomas, and 9 typical urothelial carcinomas. FISH was also used to assess the benign urothelium in 4 cases. There was a significant increase (P 75%) demonstrating homozygous 9p21 deletion. The data from this study suggest that chromosomal abnormalities detectable by FISH in urothelial carcinoma are also common in rarer histologic variants of bladder cancer. [ABSTRACT FROM AUTHOR]