학술논문
Imprinted antibody responses against SARS-CoV-2 Omicron sublineages.
Document Type
Article
Author
Young-Jun Park; Pinto, Dora; Walls, Alexandra C.; Zhuoming Liu; De Marco, Anna; Benigni, Fabio; Zatta, Fabrizia; Silacci-Fregni, Chiara; Bassi, Jessica; Sprouse, Kaitlin R.; Addetia, Amin; Bowen, John E.; Stewart, Cameron; Giurdanella, Martina; Saliba, Christian; Guarino, Barbara; Schmid, Michael A.; Franko, Nicholas M.; Logue, Jennifer K.; Dang, Ha V.
Source
Subject
*SARS disease
*IMMUNOGLOBULINS
*IMMUNITY
*VACCINES
*VACCINATION
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Language
ISSN
0036-8075
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages carry distinct spike mutations resulting in escape from antibodies induced by previous infection or vaccination. We show that hybrid immunity or vaccine boosters elicit plasma-neutralizing antibodies against Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5, and that breakthrough infections, but not vaccination alone, induce neutralizing antibodies in the nasal mucosa. Consistent with immunological imprinting, most antibodies derived from memory B cells or plasma cells of Omicron breakthrough cases cross-react with the Wuhan-Hu-1, BA.1, BA.2, and BA.4/5 receptor-binding domains, whereas Omicron primary infections elicit B cells of narrow specificity up to 6 months after infection. Although most clinical antibodies have reduced neutralization of Omicron, we identified an ultrapotent pan-variant-neutralizing antibody that is a strong candidate for clinical development. [ABSTRACT FROM AUTHOR]