학술논문
Analysis of minimal residual disease by Ig/TCR gene rearrangements: guidelines for interpretation of real-time quantitative PCR data.
Document Type
Article
Author
Source
Subject
*LYMPHOBLASTIC leukemia treatment
*DIAGNOSTIC use of polymerase chain reaction
*IMMUNOGLOBULINS
*T-cell receptor genes
*QUALITY control
*GUIDELINES
*DRUGS
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Language
ISSN
0887-6924
Abstract
Most modern treatment protocols for acute lymphoblastic leukaemia (ALL) include the analysis of minimal residual disease (MRD). To ensure comparable MRD results between different MRD-polymerase chain reaction (PCR) laboratories, standardization and quality control are essential. The European Study Group on MRD detection in ALL (ESG-MRD-ALL), consisting of 30 MRD-PCR laboratories worldwide, has developed guidelines for the interpretation of real-time quantitative PCR-based MRD data. The application of these guidelines ensures identical interpretation of MRD data between different laboratories of the same MRD-based clinical protocol. Furthermore, the ESG-MRD-ALL guidelines will facilitate the comparison of MRD data obtained in different treatment protocols, including those with new drugs.Leukemia (2007) 21, 604–611. doi:10.1038/sj.leu.2404586; published online 8 February 2007 [ABSTRACT FROM AUTHOR]