학술논문
IgH DJ rearrangements within T-ALL correlate with cCD79a expression, an immature/TCR?dphenotype and absence of IL7Ra/CD127 expression.
Document Type
Article
Author
Source
Subject
*LYMPHOID tissue
*IMMUNOGLOBULINS
*GENE expression
*INTERLEUKINS
*LEUKEMIA
*IMMUNE system
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Language
ISSN
0887-6924
Abstract
cCD79a and IgH VDJ/DJ rearrangements are considered to be relatively specific for B lymphoid precursors. We looked for both in cCD3+, CD7+, CD19- T-ALLs classified by TCR status intoaßor?d/immature (IM) lineages, with individualization of HOX11L2+T-ALLs since they represent an intermediateaß/?dcategory. cCD79a was expressed at low levels in 47%of T-ALL and was most frequent in IM?T-ALLs. IgH rearrangements were common in?d/IM (45%) and HOX11L2+(35%) T-ALLs compared to HOX11L2-negative cases (3%; P<0.001). CD127 (IL7Ra) expression was also more common in the?d/IM lineage but its expression was virtually mutually exclusive of IgH rearrangement. Low-level cCD79a expression alone should therefore not be interpreted as evidence of B lineage affiliation in immature leukemias.?d/IM lineage T-ALLs potentially include two distinct categories: predominantly IgH+, cCD79a+, CD127- cases which retain?dand B lymphoid potential and IgH-, cCD79a-, CD127+cases with restricted T lineage potential.Leukemia (2004) 18, 1997-2001. doi:10.1038/sj.leu.2403531 Published online 14 October 2004 [ABSTRACT FROM AUTHOR]