학술논문
Effectiveness and Safety of Anti-interleukin-17 Therapies in Elderly Patients with Psoriasis.
Document Type
Article
Author
PHAN, Céline; BENETON, Nathalie; DELAUNAY, Juliette; REGUIAI, Ziad; BOULARD, Claire; FOUGEROUSSE, Anne-Claire; CINOTTI, Elisa; ROMANELLI, Marco; MERY-BOSSARD, Laure; THOMAS-BEAULIEU, Domitille; PARIER, Josiane; MACCARI, François; PERROTI, Jean-Luc; RUER-MULARD, Mireille; BASTIEN, Marie; BEGON, Edouard; SAMIMI, Mahtab; JACOBZONE, Caroline; QUILES-TSIMARATOS, Nathalie; DESCAMPS, Vincent
Source
Subject
*OLDER patients
*PSORIASIS
*DISEASE relapse
*THRUSH (Mouth disease)
*OLDER people
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Language
ISSN
0001-5555
Abstract
Anti-interleukin-17 agents have recently been developed for the treatment of psoriasis. This study evaluated the tolerance and effectiveness of anti-interleukin-17 agents for psoriasis in elderly patients in daily practice. A multicentre, retrospective study was performed, involving psoriatic patients aged =65 years who had received an anti-interleukin-17 agent, including secukinumab, ixekizumab or brodalumab. A total of 114 patients were included: 72 received secukinumab, 35 ixekizumab, and 7 brodalumab. Treatment was stopped in 32 patients (28.9%), because of relapses in 14 patients (41.2%), primary failures in 11 patients (32.4%), or adverse events in 7 patients (20.6%). The 3 most frequently reported adverse events were injection site reactions (n = 4), oral candidiasis (n = 3), and influenza-like illness (n = 3). Regarding effectiveness, 80 patients (70%) reached a Physician Global Assessment score of 0/1, 6 months after treatment initiation. In conclusion, anti-interleukin-17 therapy appears to be an effective and safe therapeutic option for psoriasis treatment in patients aged = 65 years. [ABSTRACT FROM AUTHOR]