학술논문
Urate Oxidation in CSF and Blood of Patients with Inflammatory Disorders of the Nervous System.
Document Type
Article
Author
Source
Subject
*OXIDATION
*NERVOUS system
*ALLANTOIN
*MENINGITIS
*MULTIPLE sclerosis
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Language
ISSN
1525-7770
Abstract
Urate is largely excluded from the brain under non-inflammatory conditions(concentration gradient serum:CSF about 10:1), but increases markedly in Guillain–Barré Syndrome and bacterial meningitis. The oxidation product allantoin is normally not passively distributed between blood and cerebrospinal fluid(gradient 3:1) and increases 5-fold in CSF of patients with meningitis. Patients with multiple sclerosis had normal levels of urate and allantoin in blood and CSF. [ABSTRACT FROM AUTHOR]