부산대학교 도서관

Simple Summary: In recent years the first-line treatment of advanced renal cancer cell was implemented by new combination strategy. However, despite numerous research efforts, the choice of the type of treatment is still entrusted to clinical parameters. In this review we deepened the role of the complement system (CS) as a prognostic and predictive marker in kidney cancer. In particular, we described the physiology of the CS, its interaction with the tumor microenvironment and its role in oncogenesis and tumor progression. Based on the data reported in the literature, we concluded that the CS has a negative prognostic role in this pathology and its predictive role of response to immune-checkpoint inhibitors should be tested in prospective studies in order to optimize personalization of treatment for our patients, with the aim of reducing toxicity. In recent years, the first-line available therapeutic options for metastatic renal cell carcinoma (mRCC) have radically changed with the introduction into clinical practice of new immune checkpoint inhibitor (ICI)-based combinations. Many efforts are focusing on identifying novel prognostic and predictive markers in this setting. The complement system (CS) plays a central role in promoting the growth and progression of mRCC. In particular, mRCC has been defined as an "aggressive complement tumor", which encompasses a group of malignancies with poor prognosie and highly expressed complement components. Several preclinical and retrospective studies have demonstrated the negative prognostic role of the complement in mRCC; however, there is little evidence on its possible role as a predictor of the response to ICIs. The purpose of this review is to explore more deeply the physio-pathological role of the complement in the development of RCC and its possible future use in clinical practice as a prognostic and predictive factor. [ABSTRACT FROM AUTHOR]