학술논문
Finding MYCure.
Document Type
Opinion
Author
Source
Subject
*NUCLEAR proteins
*CANCER research
*GENE amplification
*TRANSCRIPTION factors
*CANCER cells
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*
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Language
ISSN
2372-3556
Abstract
Inhibiting the nuclear protein MYC involved in the majority of human cancers has long been considered an impossible mission and several technical challenges have discouraged the development of MYC inhibitory strategies. Nevertheless, in our recent publication in Science Translational Medicine "Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy", we demonstrate for the first time the feasibility of pharmacological MYC inhibition in vitro and in vivo using an Omomyc-based mini-protein. [ABSTRACT FROM AUTHOR]