학술논문
Clinical profile and outcome of cardiac manifestations in patients presenting with multisystem inflammatory syndrome in children associated with SARS-CoV-2 infection.
Document Type
Article
Author
Source
Subject
*C-reactive protein
*COVID-19
*MULTISYSTEM inflammatory syndrome
*VENTRICULAR ejection fraction
*AGE distribution
*RETROSPECTIVE studies
*REGRESSION analysis
*RISK assessment
*TREATMENT effectiveness
*DESCRIPTIVE statistics
*HEART diseases
*DISEASE risk factors
*SYMPTOMS
*CHILDREN
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Language
ISSN
0974-2069
Abstract
Multisystem inflammatory syndrome in children (MIS-C) can cause significant morbidity and mortality in children. This study was conducted to assess the pattern and outcome of cardiac abnormalities in MIS-C. This retrospective study was conducted in children with MIS-C between 1 month and 18 years. We enrolled 53 children with a mean age of 7.78 ± 4.62 years. Overall, 35.8% of children with MIS-C had cardiac manifestations in the form of coronary artery abnormalities (CAAs) or left ventricular (LV) dysfunction. Younger age (P 0.009) and high C-reactive protein at admission (P = 0.001) were significant predictors of cardiac involvement. CAAs were seen in 11.3% of children. On follow-up, 67% and 83% of children showed regression of CAA at 1 and 6 months, respectively. 24.5% of patients had presented with LV dysfunction. LV ejection fraction improved significantly at 1 month (P = 0.002) and 6 months (P = 0.001). Cardiac outcomes in MIS-C were favorable with timely identification and treatment. [ABSTRACT FROM AUTHOR]