학술논문
Chilblains outbreak during COVID‐19 pandemic: A Type‐I interferonopathy?
Document Type
Article
Author
Mensa‐Vilaró, Anna; Vicente, Asunción; Español‐Rego, Marta; Antón, Jordi; Fabregat, Virginia; Fortuny, Claudia; González, Europa Azucena; Fumadó, Victoria; González‐Roca, Eva; Jou, Cristina; Plaza, Susana; Mosquera, Juan Manuel; Yagüe, Jordi; Prat, Carolina; Pascal, Mariona; Juan, Manel; Arostegui, Juan I.; Baselga, Eulalia; Alsina, Laia
Source
Subject
*COVID-19 pandemic
*FOOT pain
*MULTISYSTEM inflammatory syndrome in children
*COVID-19
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Language
ISSN
0905-6157
Abstract
They showed type-I IFN polarization in COVID-toes patients compared with HC.13 We assessed whole blood type-I IFN signature based on the expression of 28 ISG (Table S7) in 24 patients, and we observed that 29.2% (7/24) of enrolled patients displayed increased ISG scores (Table S4 and Figure S1). Patients with COVID-toes evaluated before 7 days of onset of the skin lesions show statistical increase in 28-IRG score compared with patients who started later than 7 days. On the other hand, the strengths of our study are that we describe a relatively big and homogeneous cohort of young patients with COVID-toes, and to our knowledge, this is the first report that examines IFN signature in pediatric patients with COVID-toes. [Extracted from the article]