학술논문
Epidemiology of Pulmonary and Extrapulmonary Nontuberculous Mycobacteria Infections at 4 US Emerging Infections Program Sites: A 6-Month Pilot.
Document Type
Article
Author
Grigg, Cheri; Jackson, Kelly A; Barter, Devra; Czaja, Christopher A; Johnston, Helen; Lynfield, Ruth; Vagnone, Paula Snippes; Tourdot, Laura; Spina, Nancy; Dumyati, Ghinwa; Cassidy, P Maureen; Pierce, Rebecca; Henkle, Emily; Prevots, D Rebecca; Salfinger, Max; Winthrop, Kevin L; Toney, Nadege Charles; Magill, Shelley S
Source
Subject
*MYCOBACTERIAL disease diagnosis
*PILOT projects
*PUBLIC health surveillance
*EXTRAPULMONARY tuberculosis
*EVALUATION of human services programs
*TIME
*MYCOBACTERIUM avium
*ACQUISITION of data
*TUBERCULOSIS
*MEDICAL records
*RESEARCH funding
*DESCRIPTIVE statistics
*MYCOBACTERIAL diseases
*DATA analysis software
*COLLECTION & preservation of biological specimens
*ECONOMIC aspects of diseases
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Language
ISSN
1058-4838
Abstract
Background Nontuberculous mycobacteria (NTM) cause pulmonary (PNTM) and extrapulmonary (ENTM) disease. Infections are difficult to diagnose and treat, and exposures occur in healthcare and community settings. In the United States, NTM epidemiology has been described largely through analyses of microbiology data from health departments, electronic health records, and administrative data. We describe findings from a multisite pilot of active, laboratory- and population-based NTM surveillance. Methods The Centers for Disease Control and Prevention's Emerging Infections Program conducted NTM surveillance at 4 sites (Colorado, 5 counties; Minnesota, 2 counties; New York, 2 counties; and Oregon, 3 counties [PNTM] and statewide [ENTM]) from 1 October 2019 through 31 March 2020. PNTM cases were defined using published microbiologic criteria. ENTM cases required NTM isolation from a nonpulmonary specimen, excluding stool and rectal swabs. Patient data were collected via medical record review. Results Overall, 299 NTM cases were reported (PNTM: 231, 77%); Mycobacterium avium complex was the most common species group. Annualized prevalence was 7.5/100 000 population (PNTM: 6.1/100 000; ENTM: 1.4/100 000). Most patients had signs or symptoms in the 14 days before positive specimen collection (ENTM: 62, 91.2%; PNTM: 201, 87.0%). Of PNTM cases, 145 (62.8%) were female and 168 (72.7%) had underlying chronic lung disease. Among ENTM cases, 29 (42.6%) were female, 21 (30.9%) did not have documented underlying conditions, and 26 (38.2%) had infection at the site of a medical device or procedure. Conclusions Active, population-based NTM surveillance will provide data for monitoring the burden of disease and characterize affected populations to inform interventions. [ABSTRACT FROM AUTHOR]