학술논문
Immunotherapeutic approaches in chronic myelogenous leukemia.
Document Type
Article
Author
Source
Subject
*IMMUNOTHERAPY
*TREATMENT of chronic myeloid leukemia
*STEM cells
*THERAPEUTIC use of interferons
*VACCINATION
*DRUG therapy
*IMATINIB
*CLINICAL trials
*DISEASES
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Language
ISSN
1042-8194
Abstract
Chronic myeloid leukemia (CML) is a stem cell disease in which BCR/ABL plays an important role as oncoprotein and also as a molecular and immunogenic target. In fact, several molecular targeted drugs and immunotherapies have been developed for this disease. In the current article, several immunotherapeutic approaches in CML, including interferon-α and vaccination, are discussed along with results from clinical trials and the value of such immunotherapies in the imatinib-era. [ABSTRACT FROM AUTHOR]